雌激素替代疗法(ERT)是绝经后骨质疏松的首选治疗方案，但是长期应用后带来的子宫内膜增生、乳腺癌发生率上升等副作用也一直困扰着人们。选择性雌激素受体调节剂，通过雌激素受体调节因子，DNA反应元件等机制实现其组织选择性，保留对骨骼、心血管有益作用的同时，大大减少了对乳腺及生殖系统的副作用，目前在医学界引起广泛关注。
英文全名及说明：
Estrogen replacement therapy(ERT) is the medical administration of estrogen; it may sometimes also include the use of progestins. ERT replaces hormones which the ovaries no longer produce, either through natural or surgical menopause, and provides relief from the unpleasant symptoms of menopause such as hot flashes and night sweats.
