饶毅 博士
北京大学 终身讲席教授、生命科学学院院长
北京生命科学研究所 资深研究员,学术副所长
Yi Rao, Ph.D.
Endowed Professor, Peking University
Dean, School of Life Sciences, Peking University
Investigator and Associate Director for Academic Affairs, National Institute of Biological Sciences (NIBS), Beijing
Phone：010-8072-6672;8072-6688/368
Fax：010-8072-6673
E-mail：yrao@pku.edu.cn
研究概述：
本实验室主要兴趣在于：
1 神经发育的分子机理。
2 社会行为的分子生物学。
极性是细胞的一个基本性质。神经细胞有轴突和树突，它们起不同的作用，树突一般接受信号，而轴突通常发送信号。如果没有神经细胞的极性，神经系统的信息传递就会紊乱。实验室在分子和亚细胞水平研究神经细胞极性发生的机理，除了可以帮助基础理解以外，如果能知道怎样形成轴突，也许可以提示如何在损伤后帮助促进神经纤维再生。目前实验室主要研究调节神经细胞极性的信号转导通路。
我们通过遗传学途径研究社会行为的分子机理。主要用果蝇和鼠研究同性间争斗、异性间求偶、和亲子间抚育等行为。用可以定量的实验模型，观察行为的模式和变化。用遗传学方法，控制特定脑区神经活动，以确立脑中参与特定行为的区域。通过分析基因突变后的行为表型，找到调控行为的分子。希望理解一个行为执行需要的分子和神经通路，了解行为如何发育，行为发育的分子和细胞机理。
Research Description:
We have two major lines of research: the molecular studies of neuronal polarity in mammals and genetic analysis of social behavior.
Polarity is a basic cellular feature. Each neuron usually has an axon and multiple dendrites, each of which play different roles: axons usually send signals and dendrites receive them. Abnormalities in neuronal polarity disrupt informational flow in the nervous system. Molecular and subcellular studies of neuronal polarity will contribute to our understanding of the basic mechanisms and may also suggest new approaches to facilitate recovery after neural injuries. Our lab currently focuses on signal transduction pathways involved in establishing and maintaining neuronal polarity.
We take genetic approaches to study social behavior in Drosophila and mice. Our focus is on aggression among members of the same sex, courtship between members of the opposite sex and parental behavior between members of different generations. We use quantifiable behavioral paradigms to observe behaviors and their changes. Genetic manipulations allow us to control neuronal activities in defined regions, which make it possible to determine brain regions involved in a specific behavior. Analysis of behavioral phenotype of genetic mutations allows us to discover molecules underlying behaviors. We hope to understand the molecules and neural pathways involved in behavior and the molecular and cellular mechanisms required for the development of behaviors.
http://raolab.nibs.ac.cn/
代表性原始论文
Selected Original Papers:
1.Jiang H., Guo W., Liang X.H., and Rao Y.. Both the establishment and the maintenance of neuronal polarity require active mechanisms: critical roles of GSK-3b and its upstream regulators. Cell. 2005; 120: 123-135.
2. Liu G., Beggs H., Jürgensen C., Park H.T., Tang H., Gorski J., Jones K.R., Reichardt L.F., Wu J.Y., and Rao Y.. Netrin requires the focal adhesion kinase and the Src family kinases to induce axon outgrowth and to attract axons. Nature Neurosci. 2004; 7: 1222.
3. Ward M.E., Wu J.Y. and Rao Y.. Visualization of spatially and temporally regulated N-WASP activity during cytoskeletal reorganization in living cells. Proc Natl Acad Sci USA. 2004; 101:970-974.
4. Zhu Y., Yu T., Zhang X-C, Nagasawa T., Wu J.Y., and Rao Y.. Role of the chemokine SDF-1 as the meningeal attractant for embryonic cerebellar neurons. Nat Neurosci. 2002; 5: 719-720.
5. Wong K., Ren X-R, Huang Y-Z, Xie Y., Liu G., Saito H., Tang H., Wen L., Brady-Kalnay S.M., Mei L., Wu J.Y., Xiong W-C, and Rao Y.. Signal Transduction in Neuronal Migration: Roles of GTPase Activating Proteins and the Small GTPase Cdc42 in the Slit-Robo Pathway. Cell. 2001; 107: 209-221.
6. Wu J.Y., Feng L., Park H-T, Havlioglu N., Wen L., Tang H., Bacon K.B., Jiang Z., Zhang X-C, and Rao Y.. Slit, a molecule known to guide axon projection and neuronal migration, inhibits leukocyte chemotaxis induced by chemotactic factors. Nature. 2001; 410: 948-952.
7.Wu W., Wong K., Chen J.H., Jiang Z.H., Dupuis S., Wu J.Y., and Rao Y.. Directional guidance of neuronal migration in the olfactory system by the protein Slit. Nature. 1999; 400: 331-336.
8.Li H.S., Chen J.H., Wu W., Fagaly T., Yuan W.L., Zhou L., Dupuis S., Jiang Z., Nash W., Gick C., Ornitz D., Wu J.Y., and Rao Y.. Vertebrate Slit, a secreted ligand for the transmembrane protein Roundabout, is a repellent for olfactory bulb axons. Cell. 1999; 96: 807-818.
9.Li H.S., Tierney C., Wen L., Wu J.Y. and Rao Y.. A single morphogenetic field gives rise to two retina primordia under the influence of the prechordal mesoderm. Development. 1997; 124: 603-615.
10.Rao Y., Jan L.Y., and Jan Y.N.. Similarity of the product of the Drosophila neurogenic gene big brain to transmembrane channel proteins. Nature. 1990; 345: 163-167.
综述
Reviews
Rao Y and Wu JY (2001). A neuronal migratory pathway and the evolution of a bigger brain. Nature Neurosci. 4:860-862.
Rao Y, Wong K, Ward M, Jurgensen C, and Wu JY (2002). Neuronal migration and molecular conservation with leukocyte chemotaxis. Genes Dev 16:2973-2984.
Guan KL and Rao Y (2003). Signal transduction mechanisms mediating neuronal responses to guidance cues. Nature Rev Neurosci 4:941-956.
Ward ME and Rao Y (2004). Investigations of neuronal migration in the central nervous system. In Guan, J.-L. (ed) Cell Migration: Developmental Methods and Protocols. Humana Press, Totowa, NJ.
Liu G and Rao Y (2004). Neuronal migration in the central nervous system. The Cognitive Neurosciences, 3rd edition, Gazzaniga MS, editor in chief, MIT press.
Jiang H, and Rao Y (2005). Axon formation: fate versus growth. Nature Neurosci 8:544
