林俊生,男,华侨大学分子药物所教授。
专业背景:
生物制药,细胞生物学,分子生物学和临床医学
有关揭示Connexin50细胞连接蛋白C端对pH通道的调节作用的部份内容已被列为奥克兰大学生物学院三年级的教材(Paper Code: 405.353) 。
开发和鉴定的抗Connexin50单克隆抗体已由美国Zymed公司推向市场.本人论文被指定为该产品应用的主要指导文件(Zymed research products 2000-2001, P66) 。
有关Connexi43的研究已由新西兰和英国投资赞助开发新产品。
发明专利(基因重组成纤维细胞生长因子-8a)已获中国国家知识产权局正式授权。
基因重组卵泡刺激素卵 (FSH) 已申请发明专利,目前正在更新。
学 历:
1994-1997 博士(生物化学与分子生物学) 新西兰奥克兰大学生物学院
1990-1991 工商管理毕业文凭 澳大利亚Regent商学院
1978-1983 医学士 福建医大
工作简历:
2007- 华侨大学分子药物所教授
2006- “长江学者”评审专家
2002-2006 新西兰皇家科学院Wallaceville研究中心资深科学家
2003- 福建检验检疫局客座高级研究员
2001- 福建医大客座教授
2001- 福建省骨科研究所副所长
2001-2002 新西兰皇家农牧研究院Wallaceville研究中心科学家(生物工程)
1999-2000 新西兰奥克兰大学医学院教学研究员(生物医学)
1997-1999 新西兰奥克兰大学医学院博士后(分子生物学)
1991-1993 澳大利亚皇家阿尔弗王子医院整形外科医师 (新南威尔士注册)
1988-1989 福建医大附属第一医院总住院医师
1983-1987 福建医大附属第一医院住院医师
发明专利:
· 基因重组成纤维细胞生长因子-8a (FGF8a)(ZL01109400.1中国)
· Recombinant ovine follicle-stimulating hormone (522256, is renewing 新西兰)
· Aptamer to ovine FSH alpha (in processing新西兰)
代表性论文:
Journal articles:
Fidler, A. E., Lin, J, S., Lun, S., Ng Chie, W., Western, A., Stent, V., and McNatty, K. P. (2003) Production of biologically active tethered ovine FEHba by the methylotrophic yeast Pichia pastoris. Journal of Molecular Endocrinology, 30, 213-225
Law, L.Y., Lin, J.S., Becker, D.L., and Green, C.R. (2002 Dec) Knockdown of connexin43-mediated regulation of the zone of polarizing activity in the developing chick limb leads to digit truncation. Dev Growth Differ. 44(6):537-47.
Wright, C. S., Becker, D.L., Lin, J.S., Warner, A.E. and Hardy, K. (2001) Stage specific and differential expression of gap junctions in the mouse ovary points to connexin specific roles in follicular regulation. Reproduction, 121(1): 77-88
Eckert, R., Donaldson P., Lin, J S., Bond, J., Green C. Adams B., Merriman-Smith R., Tunstall M., and Kistler J. (2000). Gating of gap junction channels and hemichannels in the lens: a role in cataract? Current Topics in Membranes. 49:343-356.
Kistler, J; Merriman-Smith, R., Young, M., Gonen, T., Cowan, D., Chee, K-S., Lin, J S; Green, C; Hasiler, L., Engel, A. and Donaldson, P. (1999). Molecular solutions to lens transparency. NZ BioScience 7, 35-37
Lin, J.S., Eckert, R., Kistler, J., and Donaldson, P., (1998). Spatial differences in gap junction gating in the lens are a consequence of connexin cleavage. European Journal of Cell Biology. 76, 236-250.
Lin, J.S., Fitzgerald, S., Dong, Y., Knight, C. Donaldson, P., and Kistler, J. (1997). Processing of the gap junction protein connexin50 in the ocular lens is accomplished by calpain. European Journal of Cell Biology. 73, 141-149.
Book Chapters:
Becker, D L., Lin, J S. and Green, C R., (1999) Pluronic gel as a means of antisense delivery. In Antisense technology in the central nervous system., Edited by Leslie, R A., Hunter, A J., and Robertson, H A., Oxford University press, New York, pp149-157.
Green, C.R., Law, L.Y., Lin, J.S. and Becker. D.L. (2000). Spatiotemporal depletion of connexins using antisense oliogonucleotides. In Connexin Methods and Protocols. Part I Chapter 10, Edited by Bruzzone, R. and Giaume, C., Humana Press, New Jersey, pp175-185.
Kistler, J., Lin, J.S., Bond, J., Green, C., Eckert, R., Merriman, R., Tunstall, M. and Donaldson, P. (1999) Connexins in the lens: are they to blame in diabetic cataractogenesis? In Gap junction-mediated intercellular signalling in health and disease. Edited by Gilula, N.B. John Wiley & Sons Ltd, London, pp97-112.
Selected Conference Proceedings:
Lin, J. M., Watson, M., Callon, K., Lin, J., S., Grey, A., B., Naot, D., Reit I., and Cornish, F. (2005) FGF-8 Is Anabolic to Bone. Australian and New Zealand Bone and Mineral Society Annual Meeting
Lin, J. S., Western A., Lun, S., Hudson N., Bauer, E., Ng Chie, W. and McNatty, K. (2004) Production of tethered ovine FSHβα from insect cells. Queenstown Molecular Biology meeting, NZ.
Lin, J. S., Zhang, W., Law, L.Y., Stott, N. S. and Green, C.R. (2000). Upregulation of connexin43 by recombinant fibroblast growth factor (rFGF) 8a and its functional implications. Molecular Biology of the Cell, 11 (Supplement): pp225a.
Lin, J. S., Zhang, W., Law, L.Y., Stott, N. S. and Green, C.R. (2000). Connexin43 gap junction modulation of chondrogenic differentiation. Cell Biology International, 24: pp934.