VB中新建工程，添加一个按钮。
使用的时候，在IDE环境下F5运行和编译后运行就可以看到效果。
Option Explicit
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Private Declare Function GetModuleFileName Lib "kernel32" Alias _
??????? "GetModuleFileNameA" (ByVal hModule As Long, ByVal lpFileName As _
??????? String, ByVal nSize As Long) As Long
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Function IsRunUnderVB6() As Boolean
?Dim S As String
?Dim Length As Long
?Length = 256
?S = String(Length, 0)
?Call GetModuleFileName(0, S, Length)
?S = Left(S, InStr(S, Chr(0)) - 1)
?IsRunUnderVB6 = UCase(Right(S, 7)) = "VB6.EXE"
End Function
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Private Sub Command1_Click()
If IsRunUnderVB6 Then
MsgBox "调试"
Else
MsgBox "运行"
End If
End Sub
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看一看，比较简单