International Tables for Crystallography, Crystallography of Biological Macromolecules

基本信息出版社:Wiley; Volume F, 2nd Edition (2012年3月27日)丛书名:IUCr Series. International Tables of Crystallography精装:916页正文语种:英语ISBN:0470660783条形码:9780470660782商品尺寸:21 x 5.3 x 29.7 cm商品重量:3.6 KgASIN:0470660783商品描述International Tables for Crystallography Volume Fis an expert guide to macromolecular crystallography for the structural biologist. It was commissioned by theInternational Union of Crystallographyin recognition of the extraordinary contributions that knowledge of macromolecular structure has made, and will make, to the analysis of biological systems, from enzyme catalysis to the workings of a whole cell. The volume covers all stages of a crystallographic analysis from the preparation of recombinant proteins, through crystallization, diffraction data collection, phase determination, structure validation and structure analysis.Although the volume is written for experienced scientists, it is recognized that the reader is more likely to be a biologist interested in structure than a classical crystallographer interested in biology. Thus, there are chapters on the fundamentals, history and current perspectives of macromolecular crystallography, as well as on useful programs and databases such as the Protein Data Bank. Each chapter is written by one or more internationally recognized experts.This second edition features 19 new articles and many articles from the first edition have been revised. The new articles cover topics such as standard definitions for quality indicators, expression of membrane proteins, protein engineering, high-throughput crystallography, imaging of whole cells, radiation damage, merohedral twinning, low-resolution ab initio phasing, robotic crystal loading, whole-cell X-ray diffraction imaging and halogen interactions in biological crystal structures. There are also new articles on relevant software, including software for electron microscopy. These enhancements will ensure that Volume F continues to be a key reference for macromolecular crystallographers and structural biologists.