Bayesian Inference for Gene Expression and Proteomics基因表达与蛋白质组学贝氏分析
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作者： Marina Vannucci著
出 版 社：
出版时间： 2006-7-1字数：版次：页数： 437印刷时间： 2006/07/01开本： 16开印次：纸张： 胶版纸I S B N ： 9780521860925包装： 盒装内容简介
The interdisciplinary nature of bioinformatics presents a challenge in integrating concepts, methods, software, and multi-platform data. Although there have been rapid developments in new technology and an inundation of statistical methodology and software for the analysis of microarray gene expression arrays, there exist few rigorous statistical methods for addressing other types of high-throughput data, such as proteomic profiles that arise from mass spectrometry experiments. This book discusses the development and application of Bayesian methods in the analysis of high-throughput bioinformatics data, from medical research and molecular and structural biology. The Bayesian approach has the advantage that evidence can be easily and flexibly incorporated into statistical models. A basic overview of the biological and technical principles behind multi-platform high-throughput experimentation is followed by expert reviews of Bayesian methodology, tools, and software for single group inference, group comparisons, classification and clustering, motif discovery and regulatory networks, and Bayesian networks and gene interactions.
作者简介：
Kim-Anh Do is a professor in the Department of Biostatistics and Applied Mathematics and the University of Texas M.D. Anderson Cancer Center. Her research interests are in computer-intensive statistical methods with recent focus in the development of methodology and software to analyze data produced from high-throughput technologies.
Peter MOiler is also a professor in the Department of Biostatistics and Applied Mathematics and the University of Texas M.D. Anderson Cancer Center. His research interests and contributions are in the areas of Markov chain Monte Carlo posterior simulation, nonparametric Bayesian inference, hierarchical models, mixture models, and Bayesian decision problems.
Marina Vannucci is a professor of Statistics at Texas A&M University. Her research focuses on the theory and practice of Bayesian variable selection techniques and on the development of wavelet-based statistical models and their applications. Her work is often motivated by real problems that need to be addressed with suitable statistical methods.
目录
1 An Introduction to High-Throughput Bioinformatice Data
2 Hierarchical Mixture Models for Expression Profiles
3 Bayesian Hierarchical Models for Inference in Microarray Data
4 Bayesian Process-Based Modeling of Two-Channel Microarray Experimenst:Estimating Absolute mRNA Concentrations
5 Identification of Biomarkers in Classification and Clustering
6 Modeling Nonlinear Gene Interactions Using Bayesian MARAS
7 Models for Probability of Under-and Overexression:The POE Scale
8 Sparse Statistical Modelling in Gene Expression Genomics
9 Bayesian Analysis of Cell Cycle Gene Expression Data
10 Model-Based Clustering for Expression Data Via a Dirichlet Process Mixture Model
11 Interval Mapping for Expression Quantitative Trait Loci
12 Bayesian Mixture Models for Gene Expression and Protein Profiles
13 Shrinkage Estimation for SAGE Data Using a MIXTURE Dirichlet Prior
14 Analysis of mass Sectrometry Data Using Bayesian
15 Nonparametric Models for Proteomic Peak Identification and Quantification
16 Bayesian Modeling and Inference for Sequence Motif Discovery
17 Identification of DNA Reulatory Motifs and Regulators by Integration Gene Expression and Sequence data
18 A Misclassification Model for Inferring Transcriptional Reglatory Networks
19 Estimating Cellular Signaling from Transcription Data
20 Computational Methods for Learning Bayesian Networks from High-Throughput Biological Data
21 Bayesian Networks and Informative Priors:Transcriptional Regulatory Network Models
22 Sample Size Choice for Microarray Experiments
