副教授/硕士导师 高级研究助理
学科组：生物化学与分子生物学
研究方向：
1) 雄性激素受体基因表达调控与前列腺癌
2) 蛋白SUMO修饰
简历
学习经历：
1995-1997: 硕士学位，生物化学专业，Hood College, Frederick, Maryland, USA， 1986-1990: 学士学位，生物化学专业，复旦大学
工作经历：
2007-至今：副教授，华东师范大学生命科学学院生命医学研究所
2003-2007：高级研究助理，Department of Cell Biology, Baylor College of Medicine, USA.
1997-2003：研究技术员，Department of Cell Biology, Baylor College of Medicine, USA.
1990-1994：研究助理，中国科学院上海有机生化所生物化学系。
科研项目
1、2008年至今参与一项973课题，“染色质解码的基础与临床研究”。
2、参与上海市科委细胞信号传导平台建设研究。
代表性的论文
1.Chen, H.-B.,Li, J., and Yang, J. 1992. Expression of a chemically synthesized gene for the mature rbcS from tobacco inE. coli.. In”Research in Photosynthesis” (Murata, n., ed), vol. III, 645-648.
2.Stolow, M.A; Bauzon, D.D;Li, J; Sedgwick, T; Liang, V.C-T; Sang, Q.A; and Shi, Y-B. (1996). Identification and characterization of a novel collagenase inXenopus laevis: possible roles during frog development. Molecular Biology of the Cell, Vol. 7, 1471-1483.
3.Li, J; Liang, V.C-T; Sedgwick, T; Wong, J; and Shi, Y-B. 1998. Unique organization and involvement of GAGA factors in transcriptional regulation of the Xenopus stromelysin-3 gene. Nucleic Acids Res. 26(12): 3018-3025
4.Li, J., O’Malley B.W and Wong J. 2000. p300 requires its HAT activity and SRC-1 interaction motif to facilitate TR activation in chromatin. Mol. Cell. Biol. 20: 2031-2042.
5.Li, J,. Wang, J; Wang, J; Nawaz, Z; Liu, J., Jun, Q., and Wong J. 2000. Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3. EMBO J. 19(16): 4342-4350.
6. Huang, Z.,Li, J. and Wong J. 2002. Androgen receptor possesses an intrinsic-hormone-independent trans-activation activity. Molecular Endocrinology. 16: 924-937.
7.Li, J; Lin, Q; Wade, P., Wang, W and Wong J. 2002. Specific targeting and constitutive association of histone deacetylase complexes during transcriptional repression. Genes & Development 16: 687-692.
8.Li, J., Lin, Q., Yoon, H-G., Huang, Z., Strahl, B.D., Allis, C.D., and Wong J. 2002. Involvement of histone methylation and phosphorylation in regulation of transcription by thyroid hormone receptor. Mol Cell Biol 22 (16): 5688-5697.
9.Yoon HG, Chan DW, Huang ZQ,Li, J, Fondell JD, Qin J and Wong J. 2003. Purification and Functional Characterization of the Human N-CoR Complex: the Roles of HDAC3 and two WD-40 Repeat Subunits TBL1 and TBLR1. EMBO J 22(6):1336-1346.
10. Lee KC#,Li, J#, Cole PA, Wong J*and Kraus L*. 2003. Transcriptional activation by thyroid hormone receptor involves chromatin remodeling, histone acetylation, and cooperative stimulation by p300 and SRC coactivators. Molecular Endocrinology, 17(5):908-22. (#equal contribution and co-corresponding authors.)
11.Huang ZQ,Li, J, Sachs LM, Cole PA and Wong J. 2003. A Role for Cofactor-Cofactor and Cofactor-Histone Interaction in Targeting of CBP/p300, SWI/SNF and Mediator for transcription. EMBO J 22(9):2146-2155.
12.Stewart MD,Li Jand Wong J. 2005 Relationship between H3 lysine 9 methylation, transcription repression and heterochromatin protein 1 recruitment. Mol Cell Biol;25(7):2525-38.
13.Burd CJ, Petre CE, Morey LM, Wang Y, Revelo MP, Haiman CA, Lu S, Fenoglio-Preiser CM,Li J, Knudsen ES, Wong J and Knudsen KE. 2006 Cyclin D1b variant influences prostate cancer growth through aberrant androgen receptor regulation. Proc Natl Acad Sci U S A; 103:2190-5.
14.Li, J., Fu J, Toumazou C, Yoon HG, and Wong J. 2006. A role of the amino-terminal (N) and carboxyl-terminal (C) interaction in binding of androgen receptor to chromatin. Mol Endocrinol 20:776-85.
