魏成喜，男, 1982年12月生, 2005年毕业于延边大学获学士学位，2008年获得医学硕士学位。同年考取著名药物化学专家全哲山教授博士研究生，现就读于延边大学药学院药物化学专业，2009年9月，就职于内蒙古民族大学附属医院神经外科研究所。
[主要研究方向与兴趣]
一直从事药物化学科研工作，研究方向为：
1、先导化合物的寻找与结构优化。
2、临床药物新的活性筛选。
3、老年痴呆治疗机制研究。
4、心脑血管机制研究。
[主要参与的科研项目]
1. 吡唑烷酮类化合物的合成及抗癫痫作用研究，国家自然科学基金课题，2005-2007。
2．喹喔啉酮衍生物的合成及抗癫痫作用研究．国家自然科学基金课题，2008-2010。
3. 二苯甲基哌嗪类衍生物的合成和抗癫痫作用及作用机制研究。国家自然科学基金课题，2009-2011。
4. 抗癫痫新药三唑喹酮的研制，教育部重点项目，2007-2009。
5. 三唑酮并喹啉类化合物的合成及抗癫痫作用研究，教育部留学回国启动项目，2008-2010。
[获奖]
1. 延边大学医学部第七届研究生学术月论文二等奖。
2. 延边大学“第七届研究生学术活动月”优秀论文。
3. 2008届研究生科研奖。
4. 2008届研究生优秀硕士学位论文。
[近年主要发表论文]
1.Wei CX, Guan LP, Jia JH, Chai KY, Quan ZS. Synthesis of 2-substituted-6- (4H-1,2,4-triazol-4-
yl)benzo[d]oxazoles as potential anticonvulsant agents.Arch Pharm Res. 2009; 32(1):23-31.
2.Wei CX, Li FN, Zhao LX, Zhao LM, Quan ZS. Synthesis of 2-substituted-7- heptyloxy-4,5-
dihydro[1,2,4]-triazolo[4,3-a]quinolin-1(2H)-ones with anticonvulsant activity.Arch Pharm
(Weinheim).2007;340(9):491-5.
3.Wei CX, Zhang W, Quan ZS, Han RB, Jiang RS, Piao FY. Synthesis, Anticonvulsant Evaluation
of 2,3,4,5-Tetrahydro-7-alkoxy-1H-2-benzazepin- 1-ones.Letters in Drug Design & Discovery,
2009,6, 548-553
4.Wei CX, Wu D, Sun ZG, Chai KY, Quan ZS. Synthesis of 6-(3-substituted-4H- 1,2,4-triazol-4-yl)-
2-phenylbenzo[d]oxazoles as potential anticonvulsant agents.Med Chem Res. 2009. Published
online.
5.Wei CX, Deng XQ, Chai KY, Sun ZG, Quan ZS. Synthesis and Anticonvulsant Activity of 1-
Formamide-triazolo[4,3-a]quinoline Derivatives.Arch Pharm Res. 2010; 33, inpress.
6. Sun XY,Wei CX, Deng XQ, Sun ZG, Quan ZS. Evaluation of the anticonvulsant activity of 6-(4-
chlorophenyoxyl)-tetrazolo[5,1-a]phthalazine in various experimental seizure models in mice.
Pharmacol Rep. 2010, 62, 273-277.
7. Sun XY,Wei CX, Deng XQ, Sun ZG, Quan ZS. Synthesis and primary anticonvulsant activity
evaluation of 6-alkyoxyl-tetrazolo[5,1-a]phthalazine derivatives.Arzneimittelforschung.[In
press]
8. Deng XQ,Wei CX, Li FN, Sun ZG, Quan ZS. Design and synthesis of 10-alkoxy-5, 6-dihydro-
triazolo[4,3-d]benzo[f][1,4]oxazepine derivatives with anticonvulsant activity.
Eur J Med Chem. 2010 (45), 3080-3086
9. Deng XQ,Wei CX, Song MX, Chai KY, Sun ZG, and Quan ZS.Synthesis and Studies on
Anticonvulsant and Antidepressant Activities of 5-Alkoxy- tetrazolo[1,5-a] quinolines.
Bull. Korean Chem. Soc.2010, 31(2): 447-452
10. Deng XQ,Wei CX, Song MX, Quan ZS. Synthesis and antidepressant-like action of 9-alkoxy -
7H-furo[3,2-g]chromen-7-ones in mice.Arzneimittelforschung.[In press]
11. Wang HJ,Wei CX, Deng XQ, Li FL, Quan ZS. Synthesis and evaluation on anticonvulsant and
antidepressant activities of 5-Alkoxy-tetrazolo[1,5-a] quinazolines.Arch Pharm (Weinheim).
2009; 342(11): 671-5.
12. Guo LJ,Wei CX, Jia JH, Zhao LM, Quan ZS. Design and synthesis of 5-alkoxy-[1,2,4]triazolo
[4,3-a]quinoline derivatives with anticonvulsant activity.Eur J Med Chem. 2009; 44(3):954-8.
13. Guan LP,Wei CX, Deng XQ, Sui X, Piao HR, Quan ZS. Synthesis and anticonvulsant activity of
N-(2-hydroxyethyl) cinnamamide derivatives.Eur J Med Chem. 2009; 44(9): 3654-7.
14. Sun XY,Wei CX, Chai KY, Piao HR, Quan ZS. Synthesis and anti-inflammatory activity
evaluation of novel 7-alkoxy-1-amino-4,5-dihydro[1,2,4]triazole[4,3-a] quinolines.Arch Pharm
(Weinheim).2008; 341(5):288-93.
15. Zhang LQ, Guan LP,Wei CX, Deng XQ, Quan ZS. Synthesis and anticonvulsant activity of
some 7-alkoxy-2H-1,4-benzothiazin-3(4H)-ones and 7-alkoxy-4H- [1,2,4] triazolo[4,3-d]benzo[b]
[1,4]thiazines.Chem Pharm Bull (Tokyo).2010; 58(3):326-31.
16. Sun XY, Zhang L,Wei CX, Piao HR, Quan ZS. Characterization of the anticonvulsant activity
of doxepin in various experimental seizure models in mice.Pharmacol Rep. 2009; 61(2): 245-
51.
17. Zhang L, Guan LP, Sun XY,Wei CX, Chai KY, Quan ZS. Synthesis and anticonvulsant activity
of 6-alkoxy-[1,2,4]triazolo[3,4-a]phthalazines.Chem Biol Drug Des. 2009; 73(3): 313-9.
18. Sun XY, Zhang L,Wei CX, Piao HR, Quan ZS. Design, synthesis of 8-alkoxy- 5,6-dihydro-
[1,2,4]triazino[4,3-a]quinolin-1-ones with anticonvulsant activity.Eur J Med Chem.2009; 44
(3):1265-70.
19. Sun XY, Guan LP, Zhang L,Wei CX, Piao HR, Quan ZS. Design, Synthesis and Anticonvulsant
Activity Evaluation of 7-Substituted-4H-[1,2,4]triazino[3,4-a] phthalazin-4-one Derivatives.
J. Braz.Chem. Soc.2009, 20(5), 826-831.
