个人简历
1945年6月生
1970年毕业于中国科学技术大学
1978年至今,中国科学技术大学化学系任教,现为教授、博士生导师
期间:
1983-1985年,美国斯坦福大学访问学者,从事不对称合成研究
1985-1986年,美国华盛顿州立大学博士后,大环内酯新药的合成研究
1996.11-1998.2,美国佛罗里达州立大学访问教授,抗菌和抗癌新药合成研究
2001.9-2002.2,美国加州太平洋医学中心研究所,抗癌新药合成研究
主要研究方向
1 不对称合成,2 新药合成研究
目前在研的课题有:
1.野菊花中抗炎活性成分的分离、鉴别、结构修饰和活性评价(973前期,20万)
2.不对称频哪醇偶联反应研究(国家自然科学基金项目,23万)
获奖及荣誉
文章及专著
1. Li, D.-L.; Bao, H.-L.; Tan, Q.-T.; Cai, D.-M.; You, T.-P. Synthesis of Ribavirin Analogues Containing Amino Acids Residues, Synth. Commun. 2005, 35,1017..
2. Li, M-J; Jiang, C.; Li, M-Z. You. T-P., OSAR studies of 20(S)-camptothecin analogues as antitumor agents, J. Mol. Struc.: THEOCHEM, 2005, 723, 165.
3. Cai, D.-M; Lin, K.-H.; Li, M.-Z.; Wen, J.-W.; Li, H.-Y.; You, T.-P. Synthesis of Novel 1,3-Dioxolane Nucleoside Analogues, Chin. J. Chem. 2004, 22, 1425.
4. Li, Y.-G.; You, T.-P.* et al, Asymmetric pinacol coupling of aromatic aldehydes catalyzed by a new titanium-Schiff base complex, Tetrahedron:Asymmetry, 2004, 15, 1707.
5. Tian, Q.-S.; You, T.-P.* et al, Experimental and theoretical investigation of the relationship between the stericstructure of Schiff bases and the diastereoselectivity of pinacol produced from benzaldehyde, J. Mol. Cat. A: Chem. 2004, 219, 315.
6. Cai, D.-M.; You, T.-P.* et al, Ring-Expanded C-Nucleoside Analogues of Tiazofurin, Syn. Commun. 2004, 34, 159.
7. Tan, Q.-T.; You, T.-P.* et al, A Convenient Preparation of Enantiopure endo-2- Hydroxyepicamphor and endo-3-Hydroxyepicamphor From Camphoric Acid, Syn. Commun. 2004, 34, 2945.
8. Li, Y.-G.; You, T.-P.* et al, Enantioselective Pinacol Coupling of Aromatic Aldehydes Mediated by TiCl4(THF)2/Zn with Tartaric Ester, Chin. J. Chem. 2004, 22, 950.
9. Cai, D.-M.; You, T.-P.* et al, Synthesis of C-Nucleoside Analogues: 2-[2-(Hydronxymethyl)-1,3-dioxolan-5-yl]1,3-thiazole-4-carboxamide and 2-[2-(Mercapto methyl)-1,3-dioxolan-5-yl]1,3-thiazole-4-carboxamide, Chin. Chem. Lett. 2004, 15, 163.
10. Jiang, C., You, T.-P.* et al, QSAR Study of Catalytic Asymmetric Reaction with Topological Indices, J. Chem. Inf. Comput. Sci. 2003, 43, 1876
11. Tan, Q.-T.; You, T.-P.* et al, A Novel and Efficient Synthesis of Camphorquinone from Camphoric Acid, Synthesis, 2003, 12, 1869.
12. Li, Y.-G.; You, T.-P.* et al, Asymmetric Pinacol Coupling of Aromatic Aldehydes Catalyzed by TiCl4(THF)2-Zn/Chiral Diamines, Chin. J. Chem. 2003, 21, 1369.
13. Jiang, C.-S., You, T.-P.* et al, Asymmetric Cyclopropanation Catalyzed by Copper- (Schiff-Base) Complex with Double Chiral Centers, Chem. Res. Chin. U. 2003, 19(2), 238
14. Jiang, C.-S.; You, T.-P. et al, Asymmetric Cyclopropanation Catalyzed by a Series of Copper-(Schiff-Base) Complexes with Two Chiral Centers, Enantiomer, 2002, 7, 287.