G&G’S PHARMACOLOGICAL BASIS OF THERAPEUTGOODMAN&GILMAN治疗学的药理学基础
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作者： Laurence Brunton著
出 版 社：
出版时间： 2005-10-1字数：版次： 1页数： 2020印刷时间： 2005/10/01开本： 16开印次： 1纸张： 胶版纸I S B N ： 9780071422802包装： 精装内容简介
There are few technical books that remain in a leadership position for 65 years. The Pharmacological Basis of Therapeutics is one. Physicians, teachers, and medical students have voted for Goodman & Gilman with their feet and with their pocketbooks for over six decades. The question is not whether this is an important and useful text, but why?
A sentence by the original authors in their 1940 preface still describes the 11th edition: “This book has also been written for the practicing physician, to whom it offers an opportunity to keep abreast of recent advances in therapeutics and to acquire the basic principles necessary for the rational use of drugs in his/her daily practice.” The book’s 65 chapters are grouped into 15 sections: General Principles, Drugs Acting at Synaptic and Neuroeffector Junctional Sites, Drugs Acting on the Central Nervous System, Drug Therapy of Inflammation, Drugs Affecting Renal and Cardiovascular Function…Chemotherapy of Microbial Diseases, Chemotherapy of Neoplastic Diseases…Hormones and Hormone Antagonists, Dermatology, Ophthalmology, Toxicology, plus two appendices on prescription writing and patient compliance, and on the design of dosage regimens.
Reading the sections on general principles reminds one that, with the notable exception of antimicrobial and antiparasitic therapy, pharmacology is the science of altering human physiology by chemical means. The well-written chapter on treating hypertension illustrates this concept nicely; it is a pleasure to read and a vast improvement over the PDR or drug company ads. So too is the chapter on principles of antimicrobial therapy. Given the large number of authors, some chapters are easier to read than others, but none can be faulted for lack of well-organized and referenced information. Comparison of the current edition with the fifth edition of only 30 years ago provides an interesting insight into changing times. Then, the great Louis Weinstein personally wrote all the chapters on antimicrobial agents. In the current edition, five experienced and specialized physicians are required for that task.
目录
Contributors
Consultants to the Editors
Preface
Preface to the First Edition
SECTION IGENERAL PRINCIPLES
1. Pharmacokinetics and Pharmacodynamics: The Dynamics of Drug Absorption, Distribution, Action, and Elimination
2. Membrane Transporters and Drug Response
3. Drug Metabolism
4. Pharmacogenetics
5. The Science of Drug Therapy
SECTION IIDRUGS ACTING AT SYNAPTIC AND NEUROEFFECTOR JUNCTIONAL SITES
6. Neurotransmission: The Autonomic and Somatic Motor Nervous Systems
7. Muscarinic Receptor Agonists and Antagonists
8. Anticholinesterase Agents
9. Agents Acting at the Neuromuscular Junction and Autonomic Ganglia
10. Adrenergic Agonists and Antagonists
11. 5-Hydroxytryptamine (Serotonin): Receptor Agonists and Antagonists
SECTION IIIDRUGS ACTING ON THE CENTRAL NERVOUS SYSTEM
12. Neurotransmission and the Central Nervous System
13. General Anesthetics
14. Local Anesthetics
15. Therapeutic Gases: Oxygen, Carbon Dioxide, Nitric Oxide, and Helium
16. Hypnotics and Sedatives
17. Drug Therapy of Depression and Anxiety Disorders
18. Pharmacotherapy of Psychosis and Mania
19. Pharmacotherapy of the Epilepsies
20. Treatment of Central Nervous System Degenerative Disorders
21. Opioid Analgesics
22. Ethano
23. Drug Addiction and Drug Abuse
SECTION IVAUTACOIDS: DRUG THERAPY OF INFLAMMATION
24. Histamine, Bradykinin, and Their Antagonists
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