Skeletal Function and Form : Mechanobiology of Skeletal Development, Aging, and Regeneration骨骼功能与形成：骨骼发育、衰老与再生的力学生物学
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作者： Dennis R. Carter ,Gary S. Beaupré 著
出 版 社：
出版时间： 2007-8-1字数：版次： 1页数： 318印刷时间： 2007/08/01开本： 16开印次： 1纸张： 胶版纸I S B N ： 9780521714754包装： 平装内容简介
This book addresses the role of mechanical factors in the development, adaptation, maintenance, aging, and repair of skeletal tissues such as bones, cartilage, tendons, ligaments, and muscles. The authors show how the normaldeveloment of skeletal tissues is influenced by mechanical stimulation beginning in the embryo and continuing throughout life into old age. They also show how degenerative disorders such as arthritis and osteoporosis are regulated by the same mechanical processes that influence development and growth. Skeletal Function and Form bridges important gaps among disciplines and will appeal to a wide audience of bioengineers, zoologists, anthropologists, paleontologists, and orthopedists.
目录
Preface
Chapter 1. Form and Function
Historical Foundation
Skeletal Pattern Formation
Skeletal Evolution
Dermal, Perichondral, and Endochondral Bone
Bony Epiphyses and Sesamoid Bones
Mechanobiology in the Mammalian Skeleton
Human Skeletal Growth and Functional Adaptation
Chapter 2. Skeletal Tissue Histomorphology and Mechanics
Cartilage
Bone
Tendons and Ligaments
Levels of Consideration in Mechanobiology
Stress and Strain
Single-Phase Material Representations
Two-Phase Porous Hydrated Material Representations
Structural Mechanics and Stress Analysis
Chapter 3. Cartilage Differentiation and Growth
Tendon Development and Fibrocartilage Metaplasia
Secondary Cartilage
Joint Surface Morphogenesis
Chapter 4. Perichondral and Periosteal Ossification
Bone Formation
Biological and Mechanobiological Factors
Mathematical Model for Growth and Adaptation
Model Development
Normal Growth and Aging Simulations
Comparisons Between Clinical Data and Simulations
Mechanobiological Effects in Growth and Adaptation
Creating a More Complete Model
Stress/Strain Histories
Site Specificity, Lining Cells, and Time Lags
Chapter 5. Endochondral Growth and Ossification
Morphology and Biology
Biological Factors
Mechanobiological Regulation of Growth and Ossification Patterns
Mechanobiology and Endochonral Ossification Patterns
Development of the Femur
Ossification Patterns in the Sternum
Long Bone Ossification
Epiphyses and Pseudoepiphyses
Chapter 6. Cancellous Bone
Biology and Morphology
A Continuum Model Approach for Mechanically Regulated Remodeling
Normal Development and Adaptation of Cancellous Bone Architecture
Functional Adaptation Caused by Changes in Physical Activities
Modifications in Bone Structure by Biological Factors
Bone Remodeling around Implants
Creating a More Complete Model
Chapter 7. Skeletal Tissue Regeneration
Biology and Mechanobiology
The Bone-Implant Interface
Fracture Healing
Rigid Internal Fixation
Nonrigid Fixation
Pseudarthrosis
Cyclic Compression Osteogenesis vs. Distraction Osteogenesis
Neochondrogenesis and Joint Repair
Chapter 8. Articular Cartilage Development and Destruction
Growth and Ossification Near Joint Surfaces
Articular Cartilage Development and Maintenance
Joint Adaptation and Aging
Osteoarthritis
Chapter 9. Mechanobiology in Skeletal Evolution
Bone Scaling and Developmental Mechanics
Scaling Influences on Joints
Long Bone Cross Sections in Different Taxa
Bony Epiphyses and Growth Plates
Chapter 10. The Physical Nature of Living Things
AppendixA. Material Characteristics
Stress
Strain
Elastic Material Properties
Viscoelasticity and Poroelasticity
Bone
Ligament/Tendon
Cartilage
Appendix B. Structural Characteristics
Strength of Materials Approach
Experimental and Computational Stress Analysis
Appendix C. Failure Characteristics
A Simplification of Material Behavior
Monotonic Material Failure Criteria
Uniaxial Fatigue and Creep Damage
Multiaxial Fatigue
Fatigue and Strain Energy Regulation of Biology
