Matrix metalloproteinases in the central nervous system中枢神经系统中的基质金属蛋白酶
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作者： 本社 编
出 版 社：
出版时间： 2005-7-1字数：版次： 1页数： 337印刷时间： 2005/07/01开本： 16开印次： 1纸张： 胶版纸I S B N ： 9781860945595包装： 精装内容简介
This book presents the reader with an understanding of the role played by matrix metalloproteinases （MMPs） in the normal and diseased central nervous system （CNS）。 These enzymes may be important to brain development， and may also contribute to tissue destruction， which is observed with inflammatory and degenerative conditions of the brain。 The book provides a background on the biology of MMPs， and on the stimuli and conditions that are linked to an increase in their production and activity。 It describes the targets of MMPs， which include matrix proteins such as collagen， soluble cytokines and chemokines， and cell surface receptors。 Studies implicating MMPs in neuronal process outgrowth and cell migration in CNS development are covered。 The book also touches on studies suggesting that， in certain situations， dysregulated MMP activity and/or production may be critical to blood–brain barrier breakdown and neuronal damage。
目录
Foreword
Ⅰ. A Brief Overview
Chapter 1. The Matrix Metalloproteinases and Their Inhibitors
Madeleine M. Handsley，Janet Cross，Jelena Gavrilovic，and Dylan R. Edwards
Ⅱ. Regulation of MMP Expression
Chapter 2. Genetic Regulation of the Matrix Metalloproteinases and Related Proteins
Tammie Roy and Elizabeth A. Milward
Chapter 3. Post-Translational Modification
Zezong Gu， Marcus Kaul，and Stuart A. Lipton
Ⅲ. MMP Function
Chapter 4. Substrates for Metalloendopeptidases in the Central Nervous System
Paul E. Gottschall，John D. Sandy，and Dieter R. Zimmermann
Chapter 5. Examples of Signalling by MMPs
Katherine Conant
Ⅳ. MMPs and TIMPs in Development
Chapter 6. Metalloproteinases in Development Breaking Things Down to Build a Nervous System
Sarah McFarlane
Chapter 7. Matrix Metalloproteinases in Myelin Formation
Peter H. Larsen and V. Wee Yong
Chapter 8. TIMPs in CNS Development
Diane Jaworski
Ⅴ. MMPs and TIMPs in Disease
Chapter 9. Matrix Metalloproteinases in Cerebral Ischemia
Monica Wetzel， Lee Anna Cunningham，and Gary A. Rosenberg
Chapter 10. Are Matrix Metalloproteinases Detrimental or Beneficial to Artherosclerosis
Vincent Lemaitre and Jeanine D'Armiento
Chapter 11. Role and Regulation of Matrix Metalloproteases in Brain Tumours
S.Sajani Lakka， and Jasti S. Rao
Chapter 12. Matrix Metalloproteinases and Related Proteins in Alzheimer’s Disease， Parkinson's Disease and Other Neurodegenerative Disorders
Carl H. Parsons，Irene Koolwijk，Tammie Roy，Cherie Roy. Daniel Johnstone，Catharine M.P. Vos， Katherine Conant，Elizabeth A. Milward
Chapter 13. Tissue Inhibitors of Matrix Metalloproteinases， Inflammation，and The Central Nervous System
Stephen J. Crocker and Iain L. Campbell
Index
