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　　分類: 图书,进口原版书,科学与技术 Science & Techology ,

作者： Bernhard O. Palsson著

出 版 社：

出版时间： 2006-1-1字数：版次： 1页数： 322印刷时间： 2006/01/01开本： 16开印次： 1纸张： 胶版纸I S B N ： 9780521859035包装： 精装内容简介

Genome sequences are now available that enable us to determine the biological components that make up a cell or an organism. The new discipline of systems biology examines how these components interact and form networks, and how the networks generate whole cell functions corresponding to observable phenotypes. This textbook describes how to model networks, determine their properties, and relate these to phenotypic functions. Some knowledge of linear algebra and biochemistry is required, since the book reflects the irreversible trend of increasing mathematical content in biology education.

目录

Preface

1 Introduction

2 Basic Concepts in Systems Biology

PART I.RECONSTRUCTION OF BIOCHEMICAL NETWORKS

3 Metabolic Networks

4 Transcriptional Regulatory Networks

PART II.MATHEMATICAL REPRESENTATION OF RECONSTRUCTED NETWORKS

5 Signaling Networks

6 Basic Features of the Stoichiometric Matrix

7 Topological Properties

8 Fundamental Subspaces of S

9 The (Right) Null Space of S

10 The Left Null Space of S

11 The Row and Column Spaces of S

PART III CAPABILITIES OF RECONSTRUCTED NETORKS

12 Dual Causality

13 Properties of Solution Spaces

14 Sampling Solution Spaces

15 Finding Functional States

16 Parametric Sensitivity

17 Epilogue

APPENDIX A.Nomenclature and Abbreviations

APPENDIX B.E.coli Core Metabolic Network

Bibliography

Index

 

 

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