(30) If a given protein persists in the body for months or
years, some of its Amadori products slowly dehydrate and
rearrange themselves yet again, into new glucose-derived
structures. These can combine with various kinds of mol-
ecules to form irreversible structures named advanced
(35)glycosylation end products (AGE's). Most AGE's are
yellowish brown and fluorescent and have specific spec-
trographic properties. More important for the body, many
are also able to cross-link adjacent proteins, particularly
ones that give structure to tissues and organs. Although
(40)no one has yet satisfactorily described the origin of all
such bridges between proteins, many investigators agree
that extensive cross-linking of proteins probably contrib-
utes to the stiffening and loss of elasticity characteristic
of aging tissues.
(45) In an attempt to link this process with the develop-
ment of cataracts (the browning and clouding of the lens
of the eye as people age), researchers studied the effect
of glucose on solutions of purified crystallin, the major
protein in the lens of the eye. Glucose-free solutions
(50) remained clear, but solutions with glucose caused the
proteins to form clusters, suggesting that the molecules
had become cross-linked. The clusters diffracted light,
making the solution opaque. The researchers also
discovered that the pigmented cross-links in human
(55)cataracts have the brownish color and fluorescence
characteristic of AGE's. These data suggest that
nonenzymatic glycosylation of lens crystallins may
contribute to cataract formation.
參考答案:30)坚持若某一蛋白质在身体好几个月或几年, 其部分产品阿马自己慢慢脱水石板再次成为新糖源结构. 这些可以结合各种摩尔-ecules命名为先进结构形式不可逆转(35)成品糖(年龄的). 年龄最大的是土黄、荧光光谱并具体-换油性能. 更重要的是身体,也有很多可以交叉连接相邻蛋白质 尤其让那些组织和器官的结构. (40)虽然还没好形容这些桥梁的蛋白质来源, 许多调查人员认为广泛交联蛋白质可能contrib-累加到劲老化和丧失弹性的特点组织. (45)企图将这一进程的发展漏出白内障(晶状体混浊及褐变的眼睛随着人们年龄) 研究人员研究了葡萄糖对解晶体纯净、 大眼睛的水晶体蛋白质. 葡萄糖(50)无解依然清晰,但葡萄糖溶液造成蛋白质形成集群 这表明分子已成为两岸关系挂钩. 集群的衍射光,使溶液不透明. 研究人员还发现,色素两岸三通(55)人有白内障、褐色萤光年龄特点的. 这些数据表明酶促糖晶体透镜可能有助于形成白内障.
