Practical Organic Synthesis: A Student’s Guide实用有机合成： 学生指南
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作者： Reinhart Keese, Martin P. Brändle, Trevor P. Toube著
出 版 社：
出版时间： 2006-7-1字数：版次： 1页数： 199印刷时间： 2006/07/01开本： 16开印次： 1纸张： 胶版纸I S B N ： 9780470029664包装： 平装内容简介
Success in an experimental science such as chemistry depends on good laboratory practice, a knowledge of basic techniques, and the intelligent and careful handling of chemicals.
Practical Organic Synthesis is a concise, useful guide to good laboratory practice in the organic chemistry lab with hints and tips on successful organic synthesis. Topics covered include:
safety in the laboratory
environmentally responsible handling of chemicals and solvents
crystallisation
distillation
chromatographic methods
extraction and work-up
structure determination by spectroscopic methods
searching the chemical literature
laboratory notebooks
writing a report
hints on the synthesis of organic compounds
disposal and destruction of dangerous materials
drying and purifying solvents
Practical Organic Synthesis is based on a successful course in basic organic chemistry laboratory practice which has run for several years at the ETH, Zurich and the University of Berne, and its course book Grundoperationen, now in its sixth edition.
Condensing over 30 years of the authors’ organic laboratory teaching experience into one easy-to-read volume, Practical Organic Synthesis is an essential guide for those new to the organic chemistry laboratory, and a handy benchtop guide for practising organic chemists.
目录
preface
CHAPTER 1 -Accident Prevention and First Aid
1.1 Safety
1.2 Avoiding Accidents
CHAPTER 2-Environmentally Responsible Handling of Chemicals
and Solvents
2.1 Dangerous Materials: Poisons, Laws, Regulations and Classes
2.2 EU Poison Regulations
2.3 Concentration Limits
2.4 Chemical Carcinogens
CHAPTER 3- Crystallisation
CHAPTER 4- Distillation
4.1 Some Theoretical Considerations
4.2 Distillation in Practice
CHAPTER 5-Chromatographic Methods
5.1 Basic Principles
5.2 Analytical and Preparative Thin-Layer Chromatography
5.3 Column Chromatography
5.4 Rapid Column Chromatography
5.5 HPLC
CHAPTER 6-Extraction and Isolation
6.1 Separation of Mixtures According to Acidity
CHAPTER 7- Structure Determination Using Spectroscopic Methods
7.1 Infrared Spectroscopy （IR）
7.2 Mass Spectrometry （MS）
7.3 Nuclear Magnetic Resonance Spectroscopy （NMR）
7.4 Ultraviolet and Visible Spectroscopy （UV/VIS）
CHAPTER 8-Searching the Chemical Literature
8.1 The Information Mountain
8.2 Strategy
8.3 Databases
8.4 Reviews
8.5 Monographs, Reference Works and Handbooks
8.6 Data Collections
CHAPTER 9-Laboratory Notebooks
CHAPTER 1D-Writing a Report
CHAPTER 11 -Example of a Laboratory Report
CHAPTER 12-Hints on the Synthesis of Organic Compounds
12.1 The Route to Success
12.2 Some Tips on Handling Water- and Air-Sensitive Substances
12.3 Hints on Working at Low Temperatures
12.4 Hints on the Synthesis and Analysis of Chiral Compounds
12.5 Hints on the Synthesis of Isotopically Labelled Compounds
CHAPTER 13-Disposal and Destruction of Dangerous Materials
13.1 Classification of Waste Material
13.2 Environmentally Acceptable Substances for Treating Dangerous Materials in the Laboratory
13.3 Special Instructions for the Destruction of the Main Classes of Dangerous Substances
13.4 Deactivation of Unknown Laboratory Chemicals
13.5 Waste Disposal
CHAPTER 14-Purification and Drying of Solvents
14.1 Some Drying Agents
14.2 Solvents
CHAPTER 15-EU Rand SPhrases
15.1 R Phrases: Indication of Particular Risks
15.2 Combinations of R Numbers
15.3 S Phrases: Indication of Safety Precautions
15.4 Combinations of S Numbers
