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　　分類: 图书,进口原版书,科学与技术 Science & Techology ,

作者： Thisbe K. Lindhorst 著

出 版 社：

出版时间： 2007-8-20字数：版次： 1页数： 316印刷时间： 2007/08/20开本： 16开印次： 1纸张： 胶版纸I S B N ： 9783527315284包装： 平装内容简介

Concise yet complete, this is a succinct introduction to the topic, covering both basic chemistry as well as such advanced topics as high-throughput analytics and glycomics -- in one handy volume. This improved and expanded 3rd edition features all-new material on combinatorial synthesis of carbohydrates and carbohydrate biodiversity, and each chapter now contains study questions for self-learning and classroom teaching. Didactically written by an experienced lecturer and graduate student advisor, the text is backed by practical examples and more than 150 study questions tailored to students' needs.

作者简介：

Thisbe Lindhorst holds the Chair of Organic Chemistry at the University of Kiel (Germany). She graduated from Münster University in 1988, completing her Ph.D. in Organic Chemistry at the University of Hamburg in 1991. She then spent a postdoctoral period with S. G. Withers at the University of British Columbia in Vancouver (Canada) before returning to Hamburg. In 2000 she was appointed full professor at the University of Kiel.

Her research interests focus on natural product synthesis, carbohydrate and dendrimer chemistry.

目录

Contents

AbbreviatiOnS

1 Introduction

2 Structure of saccharides

2.1Structure ofmonosaccharides

2.2Structure of simple oligosaccharides

2.3Structure of p01ysaccharides

2.4Conformational analysis of saccharides Exercises andproblems

3 Protecting groups for carbohydrates

3.1Protection of the anomeric center

3.2Acyl protecting groups

3.3Ether protecting groups

3.4Acetal protecting groups

3.50rthoesters as protecting groups

3.6N-Protection for amino sugars

3.7Enymes in protecting group chemistry

3.8Carbohydrate scaffolds and orthogonality of protecting groups

3.9Protecting group patterns for allyl a-d-mannosides Exercises andproblems

4 Important modifications and functionalizatk of the sugar nng

4.1Activation-substitution reactions at the carbohydrate rin9

4.2Deoxyhalo derivatives

4.3Synthesis and reactions of anhydro sugars

4.4Deoxygenation of carbohydrates

4.5Functionalization at the anomeric center

4.6Unsaturated saccharides-Glycals

4.7Epimerizations

4.8Carbohydrates as chiral pool materials Exercises andproblems

5 O-Glycoside synthesis

5.11,2-trans Glycosidation

5.21,2-cis Glycosidation

5.3Participation of the solvent

5.4The Koenigs-Knorr method

5.5The trichloroacetimidate method

5.6Thioglycosides

5.7n-Pentenyl glycosides

5.8Synthesis of2-deoxy glycosides

5.9Synthesis of[3-mannopyranosides

5.10Synthesis of 2-deoxy-2-acetamid0-glycopyranosides

5.11Synthesis of glycopeptides

5.12Solid phase oligosaccharide synthesis

5.13Glycoside synthesis employing enzymes

5.14Glycosylation strategies

Exercises andproblems

6 Structure and biosynthesis of gIycoconjugates

6.1Structural diversity of 01igosaccharides

6.2Structures of glycoconjugates

6.2.1 Structures of glycoproteins

6.2.2 Structures of glycolipids

6.3Biosynthesis of 01igosaccharides

6.4Biosynthesis of N-glycoproteins

6.5Biosynthesis of O-glycoproteins

6.6Biosynthesis of 91ycosphingolipids

Exercises andproblems

7 Glycobiology

8 Purificatiomn and analysis of carbohydrates

9 the literature of carbohydrate chemistry

List of experimental procedures

List of tables

Subject index

 

 

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